The pharmacodynamics of Sodium Tanshinone IIA Silate

(1) Sodium Tanshinone IIA Silate coronary artery role: the treatment of coronary heart disease, improves coronary circulation, inhibit thrombosis disease. Danshensu a significant expansion of coronary artery, increase coronary blood flow, reducing myocardial oxygen consumption, heart rate and increased myocardial contractile force. After Tan ⅡA by a water-soluble substance obtained sulfonated sodium tanshinone ⅡA (Sodium TanshinonⅡA SilateA), can increase coronary blood flow, improving myocardial metabolism disorder caused by hypoxia, thereby enhancing the ability of myocardial hypoxia. There is a significant role in the protection of the red cell membrane. Animals have reduced myocardial infarct size effects. Under certain dose there inotropic effect. Its toxicity is very small. Suitable for angina pectoris, myocardial infarction and chest, it can also be used for premature ventricular contractions. Efficacy in patients with coronary heart disease and Salvia Injection similar. (2)Sodium Tanshinone IIA Silate on cardiac repair: danshensu and tanshinone IIA hypoxia can significantly prolong the time to reduce hypoxia-induced myocardial injury, while improving myocardial contractility, promote myocardial regeneration.
(3) the role of microcirculation Tan: Salvia Shuxin Capsule expansion animals arterioles, capillary net increase in the number of open, accelerate blood flow, flow, thereby improving microcirculation.
(4) Effect of tanshinone hemorrheology: danshensu and tanshinone IIA can inhibit ADP-induced platelet aggregation, inhibition of platelet TXA2 synthesis and release of vasoconstrictor substances and promote the degradation of fibrin. Can reduce coronary heart disease, stroke, cerebral ischemia and myocardial infarction patients whole blood and plasma viscosity, hematocrit reduction, through the action of viscosity reduction of anticoagulation in patients with normal blood rheology.
(5) the role of lipids Tan: In plain Salvia inhibit endogenous cholesterol synthesis, reducing the oxidation of low-density lipoprotein (LDL) is generated, reducing neutral fat can be used for atherosclerosis, hyperlipidemia caused by atherosclerosis. (6) Tan Tan ⅡA action against AS formation. Low density means the protein causes bovine vascular endothelial cell injury has a protective effect. Elevated blood cholesterol levels, particularly low-density finger protein (LDL) cholesterol concentration increased content can cause arterial endothelial cell damage, leading to atherosclerosis occurs. This study aims to evaluate the impact of the EC Tan ⅡA damage caused by LDL. Tan ⅡA has antioxidant, can prevent LDL oxidation, thereby protecting the EC, to maintain the normal function of the secretion PGL2 anti-AS formation.
(7) High quality Salvia miltiorrhiza Bge. anti-infection, and surgery for pyogenic infections (acute tonsillitis, otitis externa, osteomyelitis, surgical infections, etc.). This product is one of the active ingredients Salvia antibacterial in vitro inhibition test for M. tuberculosis H37 Rv bacteria have strong activity.
(8) High quality Salvia miltiorrhiza Bge. for the treatment of cervical erosion.
(9) Tan Tan ⅡA treat certain skin and acne.
(10) Tan Tan ⅡA treat hepatitis and leprosy.