2. The anti-inflammatory effects by gavage to rats High quality Tribulus P.E significant anti-inflammatory effect. In the first phase of the inflammatory model induced by histamine increased capillary permeability significantly inhibited; egg white, carrageenan and dextran-induced acute joint swelling inhibition; exudative peritonitis inhibit formaldehyde effect. In the second phase of the inflammation model, gelatin leukocyte migration induced mice significantly inhibited; subacute formaldehyde on joint swelling significantly inhibited. Third model of inflammation, granuloma experiment without inhibition (ie chronic phase had no effect). Tan increase rat blood PGF2α and reduced levels of PGE may be related to the anti-inflammatory mechanism of action related to Tan. 3. The anti-clotting effects of Tan has anticoagulant activity. More effective than the original child aldehyde strong tea.
4. Other effects of High quality Salvia miltiorrhiza Bge. can increase the survival rate of mice under hypoxia or prolong the survival time. Tan has anti-androgenic effect, reducing sebum production, has anti Propionibacterium acnes, and mitigate exacerbated by the bacterial metabolism of inflammation. It can be used to treat acne. Tan typhoid vaccine-induced fever in rabbits have antipyretic effects. Tan mice showed a more moderate, acting through ovarian estrogenic activity.
5. Tan observed in vivo process after duodenal administration of drugs by the liver into the bile case, the results showed that rat duodenal administration in general about 1h can be measured with a little bile discharge Tan its peak discharge after administration about 3h. Tanshinone different structures in the liver excretion rate is not the same. Further experiments also found in the bile extracted with chloroform Tan, an aqueous solution of partially denatured proteins are precipitated bile, there is a certain link between its content and different administration groups.
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